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Restoring Balance, Transforming Neurology

We are harnessing the power of light to develop a precision neuromodulation platform using optogenetics to treat severe neurological disorders.

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Our Mission

At Modulight Biotherapeutics we are pioneering a new era of brain medicine for people living with neurological disorders - one that is fast-acting, precise, and designed to provide real relief without side effects.  Our mission is to help patients regain function and comfort in moments that matter most—whether it’s stopping a seizure, calming a tremor, or easing persistent pain.

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TRIGEMINAL NEURALGIA

Our first indication for clinical studies will be debilitating neuropathic pain. The location of the trigeminal nerve makes it an ideal candidate for protein sensitive light therapy.

News & Publications

"Novel OptoGPCRs open new avenues in optogenetic modulation"

SPIE Photonics West Daily. (2025)

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"Exploring GPCR-mediated optogenetic modulation of seizure networks in a pig model of Temporal Lobe Epilepsy"

Chang, S., Bar-Or, K.L., Mivalt, F., Maltais, D., Kfir, Y., Kim, J., Kim, I., Hershko, M., Daily, J., Swissa, E., Levi, O., Devore, S., Yizhar, O., Eldar, Y., & Worrell, G. 

bioRxiv, (2025)

"Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin"

Mahn, M., Saraf-Sinik, I., Patil, P., … Lüthi, A., Rost, B.R., Wiegert, J.S. & Yizhar O. 

Neuron. 109, 10, p. 1621-1635.e8, (2021) 

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Our Research Partners

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